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These effects usually occur during the first week of treatment and resolve as the body adapts to the peptide

Treatment with tirzepatide induced a mean WC reduction ranging from 10.8 to 18.5 cm 15,16,17,18,20,21,22

Notably, cases of Saccharomyces fungemia have been reported in critically ill patients and those with central venous catheters, underscoring the need for vigilant risk assessment and monitoring in vulnerable populations (283)

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Environmental factors, including diet and micronutrient availability, may influence disease penetrance and should therefore be considered when interpreting these findings